PPI

Researchers found that while the H2 blockers had no effect on vascular aging, chronic use of the PPIs indeed impaired the lysosomes, preventing them from generating acid.  

"We also saw the telomeres shortening - they're on the tips of chromosomes and like our biological clock," Cooke added. "Those vascular cells couldn't proliferate or divide as well, and that's necessary for repairing a wound in the vessel."